Chitosan osteoarthritis gene delivery

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August undefined, 2024

WebNov 28, 2011 · Gene therapy is a promising new treatment strategy for common joint-disorders such as osteoarthritis. The development of safe, effective, targeted non-viral … WebChitosan can act itself as a precursor or carrier for medical applications such as drug delivery, gene delivery, and wound healing. With the advancement in science …

Recent advances in targeted drug delivery for treatment of osteoarthritis.

WebJan 2, 2014 · Abstract. The development of safe and efficient gene carriers is the key to the clinical success of gene therapy. The present study was designed to develop and … WebMar 3, 2006 · All these studies point to the versatility and promise of chitosan as a gene carrier, although only limited in vivo efficacy has been demonstrated. Due to the complex … subject to 意味契約書

Chondroitin sulfate modified chitosan nanoparticles as an …

WebSep 24, 2024 · 2.1. Solubility. Chitosan is produced by deacetylation of chitin; in this process, some N-acetylglucosamine moieties are converted into glucosamine units.The presence of large amounts of protonated -NH 2 groups on the chitosan structure accounts for its solubility in acid aqueous media since its pKa value is approximately 6.5 [].When … WebJun 23, 2024 · Nanoparticle-based local gene transfer can alter the expression of the endogenous genes to prevent or slow the pathological progress of OA by introducing genes, such as DNA, mRNA, siRNA, and miRNA, into the target cells. WebJan 2, 2014 · The present study was designed to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene … subject to this email

Direct chitosan-mediated gene delivery to the rabbit knee …

Chitosan - an overview ScienceDirect Topics

WebJun 6, 2024 · Chitosan is a linear copolymer composed by glucosamine and N -acteyl glucosamine units, via β- (1, 4) linkages, namely 2-amino-2-deoxy-β-d-glucan (Fig. 2 a). Chitosan is the product of the deacetylation reaction of chitin (2-acetamido-2 … WebJun 1, 2024 · Chitosan is a natural polymer with inherent antibacterial activity and a hemostasis and wound healing acceleration capability, so it has been used in drug … pain is bearableWebMar 3, 2006 · Next, chitosan–DNA nanoparticles containing IL-1Ra or IL-10 gene were injected directly into the knee joint cavities of osteoarthritis rabbits to clarify the in vivo … subject to 意味意味

"WebIntroduction. Cartilage injury, a common clinical problem, can be caused by trauma, 1 osteoarthritis, 2 rheumatoid arthritis, 3 and exfoliative chondritis. 4 Articular cartilage is … " - Chitosan osteoarthritis gene delivery

Chitosan osteoarthritis gene delivery

Chitosan-Graft-Polyethylenimine/DNA Nanoparticles as Novel …

WebApr 11, 2024 · 1.3.1.Advantageous properties of chitosan as a biomaterial. Chitosan has a structure similar to that of glycine aminoglycan, which is widely distributed in connective tissue, giving chitosan good biocompatibility (Malafaya et al., 2007).Chitosan-based biomaterials do not cause cytotoxicity or genotoxicity and promote cell proliferation and … WebApr 10, 2024 · Novel hyaluronic acid–chitosan nanoparticles as non-viral gene delivery vectors targeting osteoarthritis. International Journal of Pharmaceutics, 420 (2) (2011) ... Combining hyaluronic acid with chitosan enhances gene delivery. Journal of Nanomaterials (2014), 10.1155/2014/246347. 2014. Article 152. Google Scholar.

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WebJan 1, 2024 · Thermoresponsive DDS, chitosan-modified MoS 2 (molybdenum disulfide), was shown to release a small molecule drug, dexamethasone (Dex) ... is most commonly employed osteoarthritis therapeutic for gene delivery; currently there are two ongoing trials for intra-articular delivery using an AAV (NCT02790723) and an HDAV … WebNov 28, 2011 · Gene therapy, which treats the causes of osteoarthritis by targeting specific pathological mechanisms, is attracting much attention as a promising new treatment …

Webdesigned to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene therapy of osteoarthritis. WebJan 1, 2024 · The chitosan-based gene delivery system has several characteristics such as insignificant cellular toxicity, high gene delivery ability, targeting of particular cells, …

WebConventional treatments for osteoarthritis (OA), including drug delivery and tissue engineering approaches, could not offer a high yield of cartilage repair due to the compact and exclusive structure of cartilage. Targeted and high-efficiency delivery of gene sequences is necessary to rebalance the lost homeostatic properties of the cartilage ... WebChitosan–pDNA nanoparticle characteristics determine the transfection efficacy of gene delivery to human mesenchymal stem cells E Malakooty Poor, M Baghaban Eslaminejad, N Gheibi, F Bagheri, ... Artificial cells, nanomedicine, and biotechnology 42 (6), 376-384 , 2014

WebDec 17, 2024 · To construct a novel non-viral vector loaded with growth and differentiation factor-5 (GDF-5) plasmid using chitosan, hyaluronic acid, and chondroitin sulfate for osteoarthritis (OA) gene therapy. Methods Nano-microspheres (NMPs) were prepared by mixing chitosan, hyaluronic acid, and chondroitin sulfate.

WebDec 1, 2024 · Chitosan, a biopolymer of natural origin, has been explored for its variety of applications in biomedical research, medical diagnostic aids and material science. It is the second most abundant natural biopolymer after cellulose, and considered as an excellent excipient because of its non-toxic, stable, biodegradable properties. subject to 意味貿易WebThere are two main approaches for gene delivery using viral and non-viral gene transfer systems for treating articular cartilage defects in OA, or following joint trauma. The first is … subject to 意味数式WebJun 1, 2024 · Modifying chitosan with target ligands is a promising method for the targeted delivery of genes by delivery systems based on chitosan. Proteins, peptides, aptamers, carbohydrates, and small molecules are common ligands used to realize target delivery in gene vectors based on chitosan. pain is classified as a whatWebFeb 23, 2024 · Keywords: Osteoarthritis, Gene therapy, Chitosan, Hyaluronic acid, Chondroitin sulfate, Growth and differentiation factor-5 (GDF-5) plasmid. 1. ... HA and CHS enabled the non-viral vector itself to have some therapeutic effects on OA, making it much more suitable for delivery of gene therapy treatments for OA. painis csupo effectsWebOsteoarthritis (OA) is a painful, degenerative and inflammatory disease that affects the entire synovial joints. Nowadays, no cure exists, and the pharmacological treatments … painis cupcake theme mp3WebOct 16, 2024 · 2.2. CS-Based Modifications for Targeted Drug Delivery. When a drug enters the human body, various obstacles prevent it from reaching the disease site to elicit a specific therapeutic effect [].More importantly, drug often impart severe toxic side effects [].The current most effective strategy for solving the issues above mentioned is targeted … pain is classified as a symptom or signWebConclusions: These results suggested that HA/CS-CrmA nanoparticles could attenuate cartilage destruction and protect against early OA by inhibiting synovial inflammation via … pain is beauty saying